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a phase i and pharmacokinetic study of oral dabrafenib inrefractory chronic cough new perspectives in diagnosis

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  • Phase I and Pharmacokinetic Study of the Oral

    Sep 21 2016 · PURPOSE To evaluate the feasibility of administering the oral fluoropyrimidine capecitabine in combination with paclitaxel to characterize the principal toxicities of the combination to recommend doses for subsequent disease-directed studies and to determine whether significant pharmacokinetic interactions occur between these agents when combined. PATIENTS AND

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  • Copanlisib for the Treatment of Malignant Lymphoma

    Umbralisib is being explored for the treatment of patients with previously treated marginal zone lymphoma (MZL) and FL in the UNITY-NHL phase IIb study . The oral PI3K-δ inhibitor parsaclisib was also recently investigated in a phase II study of patients with relapsed or refractory DLBCL (CITADEL-202 NCT) the study

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  • Combining immunotherapy with oncogene Europe PMC

    Feb 09 2015 · A phase II study assessing a sequential design that combines vemurafenib followed by ipilimumab has completed patient recruitment and results are expected for 2015 (NCT). A new phase I/II trial studying concurrent treatment with dabrafenib

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  • Genomically Driven Tumors and Actionability across

    The diagnosis classification and management of cancer are traditionally dictated by the site of tumor origin for example breast or lung and by specific histologic subtypes of site-of-origin cancers (e.g. non–small cell versus small cell lung cancer). However with the advent of sequencing technologies allowing for rapid low cost and accurate sequencing of clinical samples new

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  • Actiq PA Criteria

    Reference Hájek R et al. A randomized phase III study of carfilzomib vs low-dose corticosteroids with optional cyclophosphamide in relapsed and refractory multiple myeloma (FOCUS). Leukemia. 2017 Jan31(1) . PMID NCT. Criteria for new users 1. Must have a diagnosis

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  • Pharmacogenetic and Pharmacodynamic TestingMedical

    A recent study published in the New England Journal of Medicine (Pare et al 2010) found that among patients with ACS or atrial fibrillation the effect of clopidogrel as compared with placebo is consistent irrespective of CYP2C19 genotype. Investigators genotyped patients from 2 large randomized placebo-controlled trials of the effect of

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  • A phase I clinical and pharmacokinetic study of the oral

    Thirty-five patients with advanced refractory cancer were enrolled on this phase I study of menogaril administered orally every 4 weeks at dosages ranging from 85 mg/m2 to 625 mg/m2. An additional 12 patients received alternating oral and IV doses of menogaril (250 mg/m2 IV 250–500 mg/m2 oral) with accompanying blood and urine sampling for pharmacokinetics analysis.

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  • (PDF) A Textbook of Clinical Pharmacology and Therapeutics

    24 Full PDFs related to this paper. READ PAPER. A Textbook of Clinical Pharmacology and Therapeutics

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  • Genomically Driven Tumors and Actionability across

    The diagnosis classification and management of cancer are traditionally dictated by the site of tumor origin for example breast or lung and by specific histologic subtypes of site-of-origin cancers (e.g. non–small cell versus small cell lung cancer). However with the advent of sequencing technologies allowing for rapid low cost and accurate sequencing of clinical samples new

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  • (PDF) A Textbook of Clinical Pharmacology and Therapeutics

    24 Full PDFs related to this paper. READ PAPER. A Textbook of Clinical Pharmacology and Therapeutics

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  • Full text Clinical utility of nivolumab in the treatment

    A study investigating ipilimumab plus vemurafenib in BRAF-mutated advanced melanoma patients was terminated early due to grade 3 hepatotoxicity in six out of ten patients. 50 In another Phase I study the BRAF inhibitor dabrafenib with or without the MEK inhibitor trametinib was investigated in combination with ipilimumab for V600E/K mutation

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  • Oral Communication Abstracts2017Fundamental amp

    Introduction To study i) trends in use of oral glucocorticoids (GC) in France from 2007 to 2014 ii) characteristics of new GC users and therapeutic measures associated with GC therapy over the year following treatment start. This study was part of the DRUGS‐SAFE program funded by the French Medicine Agency (ANSM).

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  • Latest Approved Therapies for Metastatic Melanoma What

    Thereby a recent multicentre open-label phase 1/2 trial (BREAK- study) investigated the efficacy and safety of oral dabrafenib in adult patients with mutant melanoma metastatic to the brain 61 62 .

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  • Full text Clinical utility of nivolumab in the treatment

    A study investigating ipilimumab plus vemurafenib in BRAF-mutated advanced melanoma patients was terminated early due to grade 3 hepatotoxicity in six out of ten patients. 50 In another Phase I study the BRAF inhibitor dabrafenib

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  • Ponatinib Monograph for ProfessionalsDrugs

    Jun 08 2020 · Efficacy determined based on response rate in a noncomparative open-label study in patients with chronic accelerated or blast phase CML or Ph ALL following failure (secondary to resistance or intolerance) of prior tyrosine kinase inhibitor therapy. 1 2 Consider whether benefit of initiating ponatinib therapy outweighs the risks. 1 (See

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  • Perspectives on cancer therapy‐induced mucosal injury

    Division of Oral Medicine Brigham Women s Hospital Boston Massachusetts. Fax (617) 232‐8970. Dr. Sonis has served as a consultant for Biomodels and Affiliates LLC (Wellesley MA). Division of Oral Medicine Brigham Women s Hospital 25 Francis Street Boston MA 02115=== Search for more papers by this author.

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  • Actiq PA Criteria

    Reference Hájek R et al. A randomized phase III study of carfilzomib vs low-dose corticosteroids with optional cyclophosphamide in relapsed and refractory multiple myeloma (FOCUS). Leukemia. 2017 Jan31(1) . PMID NCT. Criteria for new users 1. Must have a diagnosis of multiple myeloma that is relapsed or refractory 2.

    Get Price
  • The heterogeneity of chronic cough a case for endotypes

    Cough is a troublesome and difficult-to-treat symptom that accompanies a diverse range of pulmonary and extrapulmonary conditions. Although considerable advances have been made over recent years in basic cough biology this has not translated into improved clinical management. A major challenge has been in understanding the heterogeneity underlying the development and persistence of chronic

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  • Oral Communication Abstracts2017Fundamental amp

    Introduction To study i) trends in use of oral glucocorticoids (GC) in France from 2007 to 2014 ii) characteristics of new GC users and therapeutic measures associated with GC therapy over the year following treatment start. This study was part of the DRUGS‐SAFE program funded by the French Medicine Agency (ANSM).

    Get Price
  • Molecules Free Full-Text Overview of New Treatments

    According to data from the U.S. National Cancer Institute cancer is one of the leading causes of death worldwide with approximately 14 million new cases and 8.2 million cancer-related deaths in 2018. More than 60 of the new

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  • Investigational New Drugs Standard Journal Abbreviation

    Abbreviation of Investigational New Drugs. The ISO4 abbreviation of Investigational New Drugs is Invest New Drugs . It is the standardised abbreviation to be used for abstracting indexing and referencing purposes and meets all criteria of the ISO 4 standard for abbreviating names of

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  • Cephalalgia Journal Impact IF Analysis Trend

    A phase 1 study to assess the pharmacokinetics safety and tolerability of fremanezumab doses (225 mg 675 mg and 900 mg) in Japanese and Caucasian healthy subjects Predictors of response to occipital nerve stimulation in refractory chronic headache A cohort study of diagnosis

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  • Phase I and pharmacokinetic study of weekly oral therapy

    Dec 01 2001 · Original article Phase I and pharmacokinetic study of weekly oral therapy with vinorelbine in patients with advanced breast cancer (ABC) J. Bonneterre 1 email protected B. Chevalier 2 C. Focan 3 L. Mauriac 4 M. Piccart 5 1 Centre Oscar Lambret Lille Centre Oscar Lambret Lille Centre Oscar Lambret Lille 2 Centre Henri Becquerel Rouen France Centre Henri Becquerel

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  • Targeted Molecular Therapy in Palliative Cancer Management

    In a phase I study of dabrafenib 28 non-melanoma BRAF mutant malignancies were treated. There were 14 patients with papillary thyroid cancer 11 patients with colorectal cancer and one patient each with non-small-cell lung cancer gastrointestinal stromal tumor (GIST) and ovarian cancer included in the study.

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  • The November 2012 Digital Edition of Clinical Oncology

    In the study 250 patients were randomized in a 3 1 ratio to 150 mg of oral dabrafenib twice daily or 1 000 mg/m2 of DTIC administered every three weeks intravenously. The primary end point was PFS.

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  • Low-grade serous ovarian carcinoma an evolution toward

    An open-label single-arm phase II study in 52 patients with recurrent low-grade serous ovarian carcinoma investigated treatment with the oral MEK1/2 kinases inhibitor selumetinib at a dose of 50 mg twice daily.45 A total of 34 patients had tissue available for analysis of KRAS and BRAF mutation status. Two patients (6 ) had a BRAF mutation and

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  • Promising Results Shown with Targeted Approaches in

    This open-label phase II study involves patients with BRAF V600E mutant non-small cell lung cancer treated with dabrafenib alone (150 mg twice daily). The primary endpoint is investigator-assessed

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  • Issues in Pediatric and Adolescent Medicine Research and

    Issues in Pediatric and Adolescent Medicine Research and Practice 2011 Edition is a ScholarlyEditions™ eBook that delivers timely authoritative and comprehensive information about Pediatric and Adolescent Medicine Research and Practice. The editors have built Issues in Pediatric and Adolescent Medicine Research

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  • Targeted Molecular Therapy in Palliative Cancer Management

    In a phase I study of dabrafenib 28 non-melanoma BRAF mutant malignancies were treated. There were 14 patients with papillary thyroid cancer 11 patients with colorectal cancer and one patient each with non-small-cell lung cancer gastrointestinal stromal tumor (GIST) and ovarian cancer included in the study.

    Get Price

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